Products of Cytochrome P450BioI (CYP107H1)-Catalyzed Oxidation of Fatty Acids

Max J. Cryle, Nick J. Matovic, and James J. De Voss*
Department of Chemistry, University of Queensland, St. Lucia, Brisbane 4072, Australia
Org. Lett., 2003, 5 (18), pp 3341–3344
DOI: 10.1021/ol035254e
Publication Date (Web): August 15, 2003
Copyright © 2003 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, devoss@chemistry.uq.edu.au

Abstract

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Oxidation of tetradecanoic and hexadecanoic acids by cytochrome P450BioI (CYP107H1) produces mainly the 11-, 12-, and 13-hydroxy C14 fatty acids and the 11- to 15-hydroxy C16 fatty acids, respectively. In contrast to previous reports, terminal hydroxylation is not observed. The enantiospecificity of fatty acid hydroxylation by P450BioI was also determined, and the enzyme was shown to be moderately selective for production of the (R)-alcohols.

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History

  • Published In Issue September 04, 2003
  • Received July 7, 2003

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