Titanocene(III)-Promoted Reformatsky Additions

J. D. Parrish, Daniel R. Shelton, and R. Daniel Little*
Department of Chemistry and Biochemistry, University of CaliforniaSanta Barbara, Santa Barbara, California 93106-9510
Org. Lett., 2003, 5 (20), pp 3615–3617
DOI: 10.1021/ol035269c
Publication Date (Web): September 6, 2003
Copyright © 2003 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, little@chem.ucsb.edu

Abstract

Abstract Image

A novel method for the promotion of Reformatsky-like reactions is presented. The technique employs titanocene(III) chloride as a mild and homogeneous single-electron reductant. The reactions are rapid, operationally simple, and compatible with a wide range of functionalities. These additions are also anti diastereoselective.

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History

  • Published In Issue October 02, 2003
  • Received July 9, 2003

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