Highly Enantioselective Catalytic Phenylation of Ketones with a Constrained Geometry Titanium Catalyst

Celina García and Patrick J. Walsh*
Department of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104
Org. Lett., 2003, 5 (20), pp 3641–3644
DOI: 10.1021/ol0352963
Publication Date (Web): September 6, 2003
Copyright © 2003 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, pwalsh@sas.upenn.edu

Abstract

Abstract Image

The catalytic asymmetric addition of phenyl groups from diphenylzinc to ketones is reported. The catalyst, generated from a dihydroxy bis(sulfonamide) ligand and titanium tetraisopropoxide, gives good to excellent enantioselectivities with a range of substrates.

View: Full Text HTML | Hi-Res PDF

Tools

History

  • Published In Issue October 02, 2003
  • Received July 14, 2003

Recommend & Share

Related Content

Other ACS content by these authors: