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Letter

Rapid and Efficient Microwave-Assisted Amination of Electron-Rich Aryl Halides without a Transition-Metal Catalyst

Supporting Info

Lei Shi, Min Wang, Chun-An Fan, Fu-Min Zhang, and Yong-Qiang Tu*

Department of Chemistry & State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China

Org. Lett., 2003, 5 (19), pp 3515–3517

DOI: 10.1021/ol0353868

Publication Date (Web): August 20, 2003

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, tuyq@lzu.edu.cn

Abstract

A rapid and direct amination of aryl halides has been developed in good to high yields under microwave irradiation without a transition-metal catalyst. This reaction is a particularly powerful method for the coupling of electron-rich aryl halides with various amines. In some cases, the excellent regioselectivity could be observed, which facilitated the preparation of meta-substituted anilines from ortho- or para-substituted phenylhalides. In addition, a mechanism via the interesting benzyne intermediate has been proposed.

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Published In Issue September 18, 2003
Received July 24, 2003

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Letter

Rapid and Efficient Microwave-Assisted Amination of Electron-Rich Aryl Halides without a Transition-Metal Catalyst

Abstract

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SciFinder Links

History

Recommend & Share

Related Content

Copper-Catalyzed Coupling of Alkylamines and Aryl Iodides: An Efficient System Even in an Air Atmosphere

Microwave-Assisted Amination from Aryl Triflates without Base and Catalyst

Mild and Efficient Copper-Catalyzed Amination of Aryl Bromides with Primary Alkylamines

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