The First Silver-Catalyzed Three-Component Coupling of Aldehyde, Alkyne, and Amine

Chunmei Wei,†‡ Zigang Li,†‡ and Chao-Jun Li*†§;
Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, and Department of Chemistry, McGill University, 801 Sherbrooke St. West, Quebec H3A 2K6 Canada
Org. Lett., 2003, 5 (23), pp 4473–4475
DOI: 10.1021/ol035781y
Publication Date (Web): October 18, 2003
Copyright © 2003 American Chemical Society
†

 Tulane University.

,
‡

 Wei, C. M. and Li, Z. G. contributed equally to this research.

,
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

,
§

 McGill University.

, cjli@tulane.edu, ; , cj.li@mcgill.ca

Abstract

Abstract Image

Silver iodide catalyzed the three-component coupling of aldehyde, alkyne, and amines to generate propargylic amines with high efficiency in water. The silver-catalyzed reaction is especially effective for reactions involving aliphatic aldehyde. No additional cocatalyst or activator is required.

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History

  • Published In Issue November 13, 2003
  • Received September 15, 2003

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