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Letter

Catalytic, Asymmetric Synthesis of Cyanohydrin Ethyl Carbonates

Yuri N. Belokon',^† A. John Blacker,^‡ Lisa A. Clutterbuck,^§ and Michael North*^§

A.N. Nesmeyanov Institute of Organo-Element Compounds, Russian Academy of Sciences, 117813, Moscow, Vavilov 28, Russian Federation, Avecia, Ltd., P.O. Box 521, Leeds Rd. Huddersfield, West Yorkshire, HD2 1GA, UK, and Department of Chemistry, King's College London, Strand, London, WC2 R2LS, UK

Org. Lett., 2003, 5 (23), pp 4505–4507

DOI: 10.1021/ol035828f

Publication Date (Web): October 11, 2003

†

Russian Academy of Sciences.

‡

Avecia, Ltd.

King's College London.

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, michael.north@kcl.ac.uk

Abstract

The bimetallic titanium complex [(salen)TiO]₂, where salen is the ligand derived from (R,R)-cyclohexanediamine and 3,5-di-tert-butyl-salicylaldehyde, has been shown to catalyze the asymmetric addition of ethyl cyanoformate to aldehydes leading to cyanohydrin carbonates with high enantiomeric excesses.

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