Microwave-Assisted Synthesis Utilizing Supported Reagents:  A Rapid and Efficient Acylation Procedure

Daryl R. Sauer,* Douglas Kalvin, and Kathleen M. Phelan
High-Throughput Organic Synthesis Group, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064-6113
Org. Lett., 2003, 5 (24), pp 4721–4724
DOI: 10.1021/ol0358915
Publication Date (Web): November 7, 2003
Copyright © 2003 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, daryl.r.sauer@abbott.com

Abstract

Abstract Image

The application of microwave heating to a polymer-assisted solution-phase (PASP) synthesis technique has been utilized to develop a rapid and efficient protocol for the solution-phase synthesis of amides from either amine or carboxylic acid cores.

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History

  • Published In Issue November 27, 2003
  • Received September 28, 2003

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