Palladium-Catalyzed Amidation of Enol Triflates:  A New Synthesis of Enamides

Debra J. Wallace,* David J. Klauber, Cheng-yi Chen, and Ralph P. Volante
Department of Process Research, Merck Research Laboratories, P. O. Box 2000, Rahway, New Jersey 07065
Org. Lett., 2003, 5 (24), pp 4749–4752
DOI: 10.1021/ol035959g
Publication Date (Web): November 7, 2003
Copyright © 2003 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, debra_wallace@merck.com

Abstract

Abstract Image

The palladium-catalyzed coupling of a range of enol triflates with amides, carbamates, and sulfonamides has been developed. This offers a simple and widely applicable synthesis of enamides, which may not be readily available by other means.

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History

  • Published In Issue November 27, 2003
  • Received October 7, 2003

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