Synthesis of a Novel C2-Symmetric Thiourea and Its Application in the Pd-Catalyzed Cross-Coupling Reactions with Arenediazonium Salts under Aerobic Conditions

Mingji Dai,† Bo Liang,† Cuihua Wang,† Jiahua Chen,*† and Zhen Yang*†‡
Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing, 100871 China, and VivoQuest, Inc., 711 Executive Blvd., Valley Cottage, New York 10989
Org. Lett., 2004, 6 (2), pp 221–224
DOI: 10.1021/ol036182u
Publication Date (Web): December 23, 2003
Copyright © 2004 American Chemical Society
†

 Peking University.

,
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

,
‡

 VivoQuest, Inc.

, zyang@chem.pku.edu.cn.

Abstract

Abstract Image

A novel thiourea-based C2-symmetric ligand was synthesized, and its application in the palladium-catalyzed Heck and Suzuki coupling reactions of arenediazonium salts was evaluated. The reactions, which were performed at room temperature, without added base, and under aerobic conditions, produced product in 4 h with good yield. The corresponding arenediazonium salts were easily generated in one step from anilines.

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History

  • Published In Issue January 22, 2004
  • Received November 6, 2003

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