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Letter

Ortho Alkylation of Aromatic Ketimine with Functionalized Alkene by Rh(I) Catalyst

Supporting Info

Sung-Gon Lim, Jeong-Ae Ahn, and Chul-Ho Jun*

Center for Bioactive Molecular Hybrid (CBMH), Department of Chemistry, Yonsei University, Seoul 120-749, Korea

Org. Lett., 2004, 6 (25), pp 4687–4690

DOI: 10.1021/ol048095n

Publication Date (Web): November 12, 2004

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, junch@yonsei.ac.kr

Abstract

The reaction of the imine of aromatic ketones with functionalized alkenes was performed under a catalytic amount of (PPh₃)₃RhCl, and corresponding ortho-alkylated ketones were obtained after hydrolysis. A variety of functional groups in the alkene were tolerated in this ortho alkylation. This procedure expands the scope of ortho alkylation to the direct ortho functionalization of aromatic ketones.

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Published In Issue December 09, 2004
Received September 17, 2004

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Letter

Ortho Alkylation of Aromatic Ketimine with Functionalized Alkene by Rh(I) Catalyst