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Letter

Cp₂Fe(PR₂)₂PdCl₂ (R = i-Pr, t-Bu) Complexes as Air-Stable Catalysts for Challenging Suzuki Coupling Reactions

Supporting Info

Thomas J. Colacot*^† and Helene A. Shea^‡

Catalysis & Chiral Technologies, Johnson Matthey, 2001 Nolte Drive, West Deptford, New Jersey 08066, and Catalytic Services, Pharm-Eco, a Johnson Matthey Company, 25 Patton Rd, Devens, Massachusetts 01434

Org. Lett., 2004, 6 (21), pp 3731–3734

DOI: 10.1021/ol048598t

Publication Date (Web): September 17, 2004

Corresponding author. Phone: 856-384-7185.

†

Johnson Matthey.

‡

Pharm-Eco.

, colactj@jmusa.com

Abstract

The use of Cp₂Fe(PR₂)₂PdCl₂ (R = i-Pr and t-Bu) in Suzuki coupling reactions were illustrated using a high throughput screening approach. The di-tbpfPdCl₂ catalyst was shown to be the more active catalyst for unactivated and sterically challenging aryl chlorides. Comparison studies using the commercial catalysts dppfPdCl₂, (Ph₃P)₂PdCl₂, (Cy₃P)₂PdCl₂, DPEPhosPdCl₂, dppbPdCl₂, dppePdCl₂, Pd(t-Bu₃P)₂, and [Pd(μ-Br)(t-Bu₃P)]₂ were also done for selected cases to demonstrate the superior activities of di-tbpfPdCl₂ and di-isoppfPdCl₂.