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Letter

One-Pot Homolytic Aromatic Substitutions/HWE Olefinations under Microwave Conditions for the Formation of a Small Oxindole Library

Supporting Info

Antje Teichert,^† Katja Jantos,^† Klaus Harms,^† and Armido Studer*^†^‡

Fachbereich Chemie, Philipps-Universitt Marburg, 35032 Marburg, Germany. Organisch-Chemisches Institut, Westflische Wilhelms-Universitt Mnster, Corrensstrasse 40, 48149 Mnster, Germany

Org. Lett., 2004, 6 (20), pp 3477–3480

DOI: 10.1021/ol048759t

Publication Date (Web): September 2, 2004

†

Philipps-Universität Marburg.

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

‡

Westfälische Wilhelms-Universität Münster.

, studer@uni-muenster.de

Abstract

An efficient one-pot sequence comprising a homolytic aromatic substitution followed by an ionic Horner−Wadsworth−Emmons olefination for the preparation of a small library of α,β-unsaturated oxindoles is presented. Microwave-induced heating is used to conduct these reactions. The homolytic aromatic substitution is mediated by the persistent radical effect.

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Published In Issue September 30, 2004
Received June 30, 2004

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Letter

One-Pot Homolytic Aromatic Substitutions/HWE Olefinations under Microwave Conditions for the Formation of a Small Oxindole Library

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Total Synthesis of (−)-Acutumine

Asymmetric [4 + 3] Cycloadditions between Vinylcarbenoids and Dienes: Application to the Total Synthesis of the Natural Product (−)-5-epi-Vibsanin E

Palladium-Catalyzed Decarboxylative Coupling of Allylic Alkynoates with Arynes

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