Letter
Highly Efficient Stereoconservative Amidation and Deamidation of α-Amino Acids
To whom correspondence should be addressed. Phone: ++49-251-8333281. Fax: ++49-251-83-39772.
Abstract

An overall stereoconservative protection and deprotection method of amino and carboxyl groups is presented. N-Phthaloyl N‘-alkyl secondary amides of α-amino acids can be generated from corresponding N-phthaloyl amino acids by coupling reaction of N-alkylamines using mixed anhydride method. These secondary amides can be transformed by thermal rearrangement of intermediate nitrosoamides to O-alkyl esters with retention of configuration and excellent yields.
View: Full Text HTML | Hi-Res PDF
Tools
-
Add to Favorites
-
Download Citation
-
Email a Colleague -
Permalink
Order Reprints
Rights & Permissions
Citation Alerts
History
- Published In Issue October 14, 2004
- Received June 28, 2004
Cart


