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Letter

A Remarkably Efficient Coupling of Acid Chlorides with Alkynes in Water

Supporting Info

Liang Chen^† and Chao-Jun Li*^†^‡

Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, and Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, Quebec H3A 2K6, Canada

Org. Lett., 2004, 6 (18), pp 3151–3153

DOI: 10.1021/ol048789w

Publication Date (Web): July 31, 2004

†

Tulane University.

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

‡

McGill University.

, cj.li@mcgill.ca

Abstract

A highly effective direct coupling of acid chloride with terminal alkynes catalyzed by PdCl₂(PPh₃)₂/CuI together with a catalytic amount of sodium lauryl sulfate as the surfactant and K₂CO₃ as the base provided ynones in high yields in water.

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History

Published In Issue September 02, 2004
Received June 24, 2004

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Letter

A Remarkably Efficient Coupling of Acid Chlorides with Alkynes in Water