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Letter

Three-Component Synthesis of α,β-Cyclopropyl-γ-Amino Acids

Supporting Info

Peter Wipf* and Corey R. J. Stephenson

Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260

Org. Lett., 2005, 7 (6), pp 1137–1140

DOI: 10.1021/ol0501525

Publication Date (Web): February 18, 2005

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, pwipf+@pitt.edu

Abstract

The multicomponent coupling of alkenylzirconocenes with N-diphenylphosphinoyl imines provides rapid access to functionalized C-cyclopropylalkylamides which have been readily transformed into α,β-cyclopropyl-γ-amino acids. These novel scaffolds are thus accessible in ca. 8 steps from commercially available alkynes.

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Published In Issue March 17, 2005
Received January 22, 2005

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Letter

Three-Component Synthesis of α,β-Cyclopropyl-γ-Amino Acids

Abstract

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SciFinder Links

History

Recommend & Share

Related Content

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Can Two Molecules Have the Same NMR Spectrum? Hexacyclinol Revisited

Total Synthesis and Structure Elucidation of (+)-Phorbasin C

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