Letter
Synthesis of Lactams via Copper-Catalyzed Intramolecular Vinylation of Amides
In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.
Abstract

Copper-catalyzed intramolecular vinylation of iodoenamides were investigated for the first time. With CuI as the catalyst and N,N‘-dimethylethylenediamine as the ligand, a number of iodoenamides underwent cyclization in dioxane leading to the formations of five- to seven-membered lactams in moderate to excellent yields.
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History
- Published In Issue May 12, 2005
- Received March 14, 2005
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