Synthesis of Lactams via Copper-Catalyzed Intramolecular Vinylation of Amides

Tianshun Hu and Chaozhong Li*
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, P. R. China
Org. Lett., 2005, 7 (10), pp 2035–2038
DOI: 10.1021/ol0505555
Publication Date (Web): April 9, 2005
Copyright © 2005 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, clig@mail.sioc.ac.cn

Abstract

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Copper-catalyzed intramolecular vinylation of iodoenamides were investigated for the first time. With CuI as the catalyst and N,N-dimethylethylenediamine as the ligand, a number of iodoenamides underwent cyclization in dioxane leading to the formations of five- to seven-membered lactams in moderate to excellent yields.

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History

  • Published In Issue May 12, 2005
  • Received March 14, 2005

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