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Letter

N-Heterocyclic Carbene-Catalyzed Amidation of Unactivated Esters with Amino Alcohols

Supporting Info

Mohammad Movassaghi* and Michael A. Schmidt

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Org. Lett., 2005, 7 (12), pp 2453–2456

DOI: 10.1021/ol050773y

Publication Date (Web): May 17, 2005

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, movassag@mit.edu

Abstract

A catalytic amidation of unactivated esters with amino alcohols is described. A series of solution studies in addition to the first X-ray structure of a carbene−alcohol complex support a carbene-base nucleophile activation mechanism.

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Published In Issue June 09, 2005
Received April 10, 2005

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Letter

N-Heterocyclic Carbene-Catalyzed Amidation of Unactivated Esters with Amino Alcohols

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

N-Heterocyclic Carbene-Catalyzed Redox Amidations of α-Functionalized Aldehydes with Amines

Catalytic Generation of Activated Carboxylates: Direct, Stereoselective Synthesis of β-Hydroxyesters from Epoxyaldehydes

Applications of 1-Alkenyl-1,1-Heterobimetallics in the Stereoselective Synthesis of Cyclopropylboronate Esters, Trisubstituted Cyclopropanols and 2,3-Disubstituted Cyclobutanones

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