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Letter

Synthesis of Fused Bicyclic Imidazoles by Sequential Van Leusen/Ring-Closing Metathesis Reactions

Supporting Info

Vijaya Gracias,* Alan F. Gasiecki, and Stevan W. Djuric

Scaffold-Oriented Synthesis, Medicinal Chemistry Technologies, Abbott Laboratories, R4CP, AP10, 100 Abbott Park Road, Abbott Park, Illinois 60064-6099

Org. Lett., 2005, 7 (15), pp 3183–3186

DOI: 10.1021/ol050852+

Publication Date (Web): June 28, 2005

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, vijaya.gracias@abbott.com

Abstract

A new strategy employing the van Leusen three-component reaction and the ring-closing metathesis reaction in a sequential fashion to access fused bicyclic imidazole rings is reported. The two-step sequence generated compounds of significant molecular complexity from simple starting materials in an expedient fashion with excellent yields.

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Published In Issue July 21, 2005
Received April 18, 2005

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Letter

Synthesis of Fused Bicyclic Imidazoles by Sequential Van Leusen/Ring-Closing Metathesis Reactions

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Total Synthesis of (−)-Serotobenine

Total Synthesis of (−)-Penifulvin A, an Insecticide with a Dioxafenestrane Skeleton

Novel Multicomponent Reaction for the Combinatorial Synthesis of 2-Imidazolines

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