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Letter

Efficient Pd-Catalyzed Amination of Heteroaryl Halides

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Mark D. Charles, Phillip Schultz, and Stephen L. Buchwald*

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Org. Lett., 2005, 7 (18), pp 3965–3968

DOI: 10.1021/ol0514754

Publication Date (Web): August 10, 2005

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, sbuchwal@mit.edu

Abstract

The Pd-catalyzed amination of a variety of heteroaryl halides has been accomplished by utilizing bulky electron-rich biaryl phosphine ligands. In particular, we report the first couplings of amines with chloro- and bromoindoles bearing a free NH, as well as the first Pd-catalyzed aminations of a 5-halopyrimidine.

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Published In Issue September 01, 2005
Received June 23, 2005

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Letter

Efficient Pd-Catalyzed Amination of Heteroaryl Halides

Abstract

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SciFinder Links

History

Recommend & Share

Related Content

A New Class of Easily Activated Palladium Precatalysts for Facile C−N Cross-Coupling Reactions and the Low Temperature Oxidative Addition of Aryl Chlorides

Scope and Limitations of the Pd/BINAP-Catalyzed Amination of Aryl Bromides

Pd-Catalyzed Amidations of Aryl Chlorides Using Monodentate Biaryl Phosphine Ligands: A Kinetic, Computational, and Synthetic Investigation

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