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Letter

Direct β-Alkylation of Secondary Alcohols with Primary Alcohols Catalyzed by a Cp*Ir Complex

Supporting Info

Ken-ichi Fujita,* Chiho Asai, Tetsuhiro Yamaguchi, Fumihiro Hanasaka, and Ryohei Yamaguchi*;

Graduate School of Human and Environmental Studies, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan

Org. Lett., 2005, 7 (18), pp 4017–4019

DOI: 10.1021/ol051517o

Publication Date (Web): August 2, 2005

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, fujitak@kagaku.mbox.media.kyoto-u.ac.jp, ; , yama@kagaku.mbox.media.kyoto-u.ac.jp

Abstract

A new catalytic system for β-alkylation of secondary alcohols has been developed. In the presence of [Cp*IrCl₂]₂ (Cp* = pentamethylcyclopentadienyl) catalyst and base, the reactions of various secondary alcohols with primary alcohols give β-alkylated higher alcohols in good to excellent yields without any hydrogen acceptor or hydrogen donor. This reaction proceeds via successive hydrogen-transfer reactions and aldol condensation.

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Published In Issue September 01, 2005
Received June 29, 2005

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Letter

Direct β-Alkylation of Secondary Alcohols with Primary Alcohols Catalyzed by a Cp*Ir Complex

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Ligand-Promoted Dehydrogenation of Alcohols Catalyzed by Cp*Ir Complexes. A New Catalytic System for Oxidant-Free Oxidation of Alcohols

Ruthenium-Catalyzed One-Pot β-Alkylation of Secondary Alcohols with Primary Alcohols

Iridium-Catalyzed Conversion of Alcohols into Amides via Oximes

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