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Letter

Suzuki−Miyaura Cross-Coupling of Benzylic Phosphates with Arylboronic Acids

Supporting Info

Mark McLaughlin*

Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065

Org. Lett., 2005, 7 (22), pp 4875–4878

DOI: 10.1021/ol0517271

Publication Date (Web): October 6, 2005

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, mark_mclaughlin@merck.com

Abstract

Suzuki−Miyaura cross-coupling of benzylic phosphates with arylboronic acids was investigated. Optimum conditions employed the simple catalytic system of palladium(II) acetate (1 mol %) and triphenylphosphine (4 mol %) with either potassium phosphate or potassium carbonate as the base and toluene as the solvent at 90 °C. Using the developed conditions, a series of structurally diverse diarylmethanes were prepared.

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Published In Issue October 27, 2005
Received July 21, 2005

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Letter

Suzuki−Miyaura Cross-Coupling of Benzylic Phosphates with Arylboronic Acids

Abstract

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Recommend & Share

Related Content

Suzuki−Miyaura Cross-Coupling of Benzylic Carbonates with Arylboronic Acids

Suzuki−Miyaura Cross-Coupling Reactions of Benzyl Halides with Potassium Aryltrifluoroborates

Synthesis of Functionalized Diarylmethanes via a Copper-Catalyzed Cross-Coupling of Arylmagnesium Reagents with Benzylic Phosphates

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