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Letter

Diphenylprolinol Methyl Ether: A Highly Enantioselective Catalyst for Michael Addition of Aldehydes to Simple Enones

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Yonggui Chi and Samuel H. Gellman*

Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706

Org. Lett., 2005, 7 (19), pp 4253–4256

DOI: 10.1021/ol0517729

Publication Date (Web): August 18, 2005

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, gellman@chem.wisc.edu

Abstract

Diphenylprolinol methyl ether catalyzes intermolecular Michael addition of simple aldehydes to relatively nonactivated enones with the highest enantioselectivities reported to date (95−99% ee) and significantly lower catalyst loadings than have been typical in this arena.

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Published In Issue September 15, 2005
Received July 26, 2005

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Letter

Diphenylprolinol Methyl Ether: A Highly Enantioselective Catalyst for Michael Addition of Aldehydes to Simple Enones

Abstract

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SciFinder Links

History

Recommend & Share

Related Content

Catalytic Direct Asymmetric Michael Reactions: Taming Naked Aldehyde Donors

Enantioselective Organocatalytic Michael Additions of Aldehydes to Enones with Imidazolidinones: Cocatalyst Effects and Evidence for an Enamine Intermediate

Direct Enantioselective Michael Addition of Aldehydes to Vinyl Ketones Catalyzed by Chiral Amines

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