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Letter

One-Pot Construction of Pyrazoles and Isoxazoles with Palladium-Catalyzed Four-Component Coupling

Supporting Info

Mohamed S. Mohamed Ahmed, Kei Kobayashi, and Atsunori Mori*

Chemical Resources Laboratory, Tokyo Institute of Technology, R1-4 4259 Nagatsuta, Yokohama 226-8503, Japan

Org. Lett., 2005, 7 (20), pp 4487–4489

DOI: 10.1021/ol051841j

Publication Date (Web): September 1, 2005

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, amori@res.titech.ac.jp

Abstract

Four-component coupling of a terminal alkyne, hydrazine (hydroxylamine), carbon monoxide, and an aryl iodide furnishes pyrazole or isoxazole derivatives in the presence of a palladium catalyst. The reaction proceeds at room temperature and an ambient pressure of carbon monoxide in an aqueous solvent system.

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Published In Issue September 29, 2005
Received August 1, 2005

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Letter

One-Pot Construction of Pyrazoles and Isoxazoles with Palladium-Catalyzed Four-Component Coupling

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

1,3-Diketones from Acid Chlorides and Ketones: A Rapid and General One-Pot Synthesis of Pyrazoles

A Novel One-Pot Method for the Preparation of Pyrazoles by 1,3-Dipolar Cycloadditions of Diazo Compounds Generated in Situ

Synthesis of Isoxazoles via Electrophilic Cyclization

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