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Letter

CuI/l-Proline-Catalyzed Coupling Reactions of Aryl Halides with Activated Methylene Compounds

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Xiaoan Xie,^† Guorong Cai,^† and Dawei Ma*^‡

Department of Chemistry, Fudan University, Shanghai 200433, China, and State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China

Org. Lett., 2005, 7 (21), pp 4693–4695

DOI: 10.1021/ol0518838

Publication Date (Web): September 23, 2005

†

Fudan University.

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

‡

Chinese Academy of Sciences.

, madw@pub.sioc.ac.cn

Abstract

The arylation of ethyl acetoacetate, ethyl benzoyl acetate, and diethyl malonate under the catalysis of CuI/l-proline in DMSO proceeds smoothly at 40−50 °C in the presence of Cs₂CO₃ to provide the 2-aryl-1,3-dicarbonyl compounds in good yields. Both aryl iodides and aryl bromides are compatible with these reaction conditions.

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Published In Issue October 13, 2005
Received August 5, 2005

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Letter

CuI/l-Proline-Catalyzed Coupling Reactions of Aryl Halides with Activated Methylene Compounds

Abstract

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Related Content

A General and Mild Copper-Catalyzed Arylation of Diethyl Malonate

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Mild Method for Ullmann Coupling Reaction of Amines and Aryl Halides

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