Letter
NaIO4/LiBr-mediated Diastereoselective Dihydroxylation of Olefins: A Catalytic Approach to the Prevost−Woodward Reaction
Corresponding author. Phone: +91-020-25902174. Fax: +91-20-25893359.
Abstract

LiBr catalyzes efficiently the dihydroxylation of alkenes to afford syn and anti diols with excellent diastereoselectivity depending upon the use of NaIO4 (30 mol %) or PhI(OAc)2 (1 equiv), respectively, as the oxidants. The oxidation of non-benzylic halides has been achieved for the first time to afford the corresponding diols in excellent yields.
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History
- Published In Issue October 27, 2005
- Received August 29, 2005
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