Chiral Phosphite-oxazolines:  A New Class of Ligands for Asymmetric Heck Reactions

Yvette Mata, Montserrat Diéguez,* Oscar Pàmies,* and Carmen Claver;
Departament de Qumica Fsica i Inorgnica, Universitat Rovira i Virgili, C/Marcelli Domingo, s/n, 43007 Tarragona, Spain
Org. Lett., 2005, 7 (25), pp 5597–5599
DOI: 10.1021/ol052176h
Publication Date (Web): November 12, 2005
Copyright © 2005 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, montserrat.dieguez@urv.net, ; , oscar.pamies@urv.net

Abstract

Abstract Image

A series of phosphite-oxazoline ligands, derived from readily available d-glucosamine, have been used for the first time in the palladium-catalyzed Heck reaction of several substrates with high regio- and enantioselectivities (ee's up to 99%) and improved activities in standard conditions.

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History

  • Published In Issue December 08, 2005
  • Received September 9, 2005

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