Intramolecular Alkyne Hydroalkoxylation and Hydroamination Catalyzed by Iridium Hydrides

Xingwei Li, Anthony R. Chianese, Tiffany Vogel, and Robert H. Crabtree*
Department of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520-8107
Org. Lett., 2005, 7 (24), pp 5437–5440
DOI: 10.1021/ol052186i
Publication Date (Web): October 27, 2005
Copyright © 2005 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, robert.crabtree@yale.edu

Abstract

Abstract Image

Iridium(III) hydrides prove to be air-stable active catalysts for intramolecular hydroalkoxylation and hydroamination of internal alkynes with proximate nucleophiles. The cyclization follows highly selective 6-endo-dig regiochemistry when regioselectivity is an issue.

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History

  • Published In Issue November 24, 2005
  • Received September 11, 2005

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