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Letter

C₂-Symmetric Bisprolinamide as a Highly Efficient Catalyst for Direct Aldol Reaction

Supporting Info

Sampak Samanta, Jinyun Liu, Rajasekhar Dodda, and Cong-Gui Zhao*

Department of Chemistry, University of Texas at San Antonio, 6900 North Loop 1604 West, San Antonio, Texas 78249-0698

Org. Lett., 2005, 7 (23), pp 5321–5323

DOI: 10.1021/ol052277f

Publication Date (Web): October 6, 2005

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, cong.zhao@utsa.edu

Abstract

The catalytic activity of the prolinamide-type catalysts may be improved by introducing additional prolinamide moiety into the catalyst, while the enantioselectivity can still be maintained or further improved. A C₂-symmetric bisprolinamide with two prolinamide moieties has been found to be an excellent catalyst for direct aldol reaction with more than doubled reactivity and better asymmetric induction than its monoprolinamide counterpart.

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Published In Issue November 10, 2005
Received September 20, 2005

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Letter

C₂-Symmetric Bisprolinamide as a Highly Efficient Catalyst for Direct Aldol Reaction