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Letter

[3+2] Cross-Coupling Reactions of Aziridines with Isocyanates Catalyzed by Nickel(II) Iodide

Supporting Info

Takeshi Munegumi,^† Isao Azumaya,^‡ Takako Kato,^‡ Hyuma Masu,^‡ and Shinichi Saito*^†

Department of Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku, Tokyo, Japan 162-8601, and Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Kagawa, Japan 769-2193

Org. Lett., 2006, 8 (3), pp 379–382

DOI: 10.1021/ol052417l

Publication Date (Web): January 17, 2006

†

Tokyo University of Science.

‡

Tokushima Bunri University.

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, ssaito@rs.kagu.tus.ac.jp

Abstract

Cycloaddition of aziridines with isocyanates proceeded smoothly in the presence of a nickel catalyst, and five iminooxazolidine derivatives were isolated in good yields. The best result was obtained when the reaction was carried out in the presence of NiI₂, and a longer reaction time allowed the isomerization of the iminooxazolidine to the corresponding imidazolidinone derivatives.

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Published In Issue February 02, 2006
Received October 6, 2005

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Letter

[3+2] Cross-Coupling Reactions of Aziridines with Isocyanates Catalyzed by Nickel(II) Iodide

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Phosphine-Promoted [3 + 3] Annulations of Aziridines With Allenoates: Facile Entry Into Highly Functionalized Tetrahydropyridines

Palladium-Catalyzed Asymmetric Dearomatization of Naphthalene Derivatives

Iridium-Catalyzed Addition of Acid Chlorides to Terminal Alkynes

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