Aerobic Oxidative Cyclization under Pd(II) Catalysis:  A Regioselective Approach to Heterocycles

Kai-Tai Yip, Jin-Heng Li, On-Yi Lee, and Dan Yang*
Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China
Org. Lett., 2005, 7 (25), pp 5717–5719
DOI: 10.1021/ol052529c
Publication Date (Web): November 8, 2005
Copyright © 2005 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, yangdan@hku.hk

Abstract

Abstract Image

An efficient Yb(OTf)3-promoted palladium-catalyzed oxidative cyclization of γ-heteroalkenyl β-keto amides has been developed. Under simple aerobic condition, a variety of six-, seven-, and eight-membered-ring N- and O-heterocycles were obtained regioselectively in excellent yield.

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History

  • Published In Issue December 08, 2005
  • Received October 19, 2005

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