Noncryogenic I/Br−Mg Exchange of Aromatic Halides Bearing Sensitive Functional Groups Using i-PrMgCl−Bis[2-(N,N-dimethylamino)ethyl] Ether Complexes

Related Content

• Addition of Grignard Reagents to Aryl Acid Chlorides:  An Efficient Synthesis of Aryl KetonesOrganic Letters

  • Addition of Grignard Reagents to Aryl Acid Chlorides:  An Efficient Synthesis of Aryl Ketones

    Xiao-jun Wang, Li Zhang, Xiufeng Sun, Yibo Xu, Dhileepkumar Krishnamurthy, and Chris H. Senanayake
    Organic Letters 2005 7 (25), pp 5593–5595

    Abstract: Direct addition of Grignard reagents to acid chlorides in the presence of bis[2-(N,N-dimethylamino)ethyl] ether proceeds selectively to provide aryl ketones in high yields. A possible tridentate interaction between Grignard reagents and bis[2-(N,N-...

    Abstract | Full Text HTML | Hi-Res PDF
• A General Solution for Unstable Boronic Acids: Slow-Release Cross-Coupling from Air-Stable MIDA BoronatesJournal of the American Chemical Society

  • A General Solution for Unstable Boronic Acids: Slow-Release Cross-Coupling from Air-Stable MIDA Boronates

    David M. Knapp, Eric P. Gillis and Martin D. Burke
    Journal of the American Chemical Society 2009 131 (20), pp 6961–6963

    Abstract: Many boronic acids, including 2-heterocyclic, vinyl, and cyclopropyl derivatives, are inherently unstable, which can limit their benchtop storage and/or efficient cross-coupling. We herein report the first general solution to this problem: in situ slow ...

    Abstract | Full Text HTML | PDF w/ Links | Hi-Res PDF
• Stereoselective Construction of Seven-Membered Rings with an All-Carbon Quaternary Center by Direct Tiffeneau−Demjanov-type Ring ExpansionJournal of the American Chemical Society

  • Stereoselective Construction of Seven-Membered Rings with an All-Carbon Quaternary Center by Direct Tiffeneau−Demjanov-type Ring Expansion

    Takuya Hashimoto, Yuki Naganawa and Keiji Maruoka
    Journal of the American Chemical Society 2009 131 (18), pp 6614–6617

    Abstract: Insertion of one methylene unit into the C−C bond of cyclohexanones is a potentially useful, straightforward method for the construction of seven-membered carbocycles. An especially appealing but largely unexplored method in this arena is the nucleophilic ...

    Abstract | Full Text HTML | PDF w/ Links | Hi-Res PDF

Other ACS content by these authors:

• Xiao-jun Wang
• Xiufeng Sun
• Li Zhang
• Yibo Xu
• Dhileepkumar Krishnamurthy
• Chris H. Senanayake