A Short Total Synthesis of (±)-Aspidospermidine

Lisa A. Sharp and Samir Z. Zard*
Laboratoire de Synthse Organique associ au CNRS, cole Polytechnique, 91128 Palaiseau, France
Org. Lett., 2006, 8 (5), pp 831–834
DOI: 10.1021/ol052749q
Publication Date (Web): February 8, 2006
Copyright © 2006 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, zard@poly.polytechnique.fr

Abstract

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A cascade radical cyclization starting from an amidyl radical has been used for the construction of (±)-aspidospermidine. This approach has also been developed for the preparation of a tricycle whose framework is contained in the stemona alkaloids.

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History

  • Published In Issue March 02, 2006
  • Received November 14, 2005

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