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Letter

Pd/C-Catalyzed Deoxygenation of Phenol Derivatives Using Mg Metal and MeOH in the Presence of NH₄OAc

Supporting Info

Hironao Sajiki,* Akinori Mori, Tomoteru Mizusaki, Takashi Ikawa, Tomohiro Maegawa, and Kosaku Hirota

Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, Mitahora-higashi, Gifu 502-8585, Japan

Org. Lett., 2006, 8 (5), pp 987–990

DOI: 10.1021/ol060045q

Publication Date (Web): February 2, 2006

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, sajiki@gifu-pu.ac.jp

Abstract

A Pd/C-catalyzed deoxygenation method of phenolic hydroxyl groups via aryl triflates or mesylates using Mg metal in MeOH at room temperature was developed. The addition of NH₄OAc dramatically affects the reactivity and reaction rate. This method is particularly attractive to provide an environmentally benign and widely applicable removal method of phenolic alcohols under quite mild reaction conditions.

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History

Published In Issue March 02, 2006
Received January 8, 2006

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Letter

Pd/C-Catalyzed Deoxygenation of Phenol Derivatives Using Mg Metal and MeOH in the Presence of NH₄OAc