New Air-Stable Catalysts for General and Efficient Suzuki−Miyaura Cross-Coupling Reactions of Heteroaryl Chlorides

Anil S. Guram,* Anthony O. King, John G. Allen, Xianghong Wang, Laurie B. Schenkel, Johann Chan, Emilio E. Bunel, Margaret M. Faul, Robert D. Larsen, Michael J. Martinelli, and Paul J. Reider
Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320
Org. Lett., 2006, 8 (9), pp 1787–1789
DOI: 10.1021/ol060268g
Publication Date (Web): April 1, 2006
Copyright © 2006 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, aguram@amgen.com

Abstract

Abstract Image

New air-stable PdCl2{PtBu2(p-R-Ph)}2 (R = H, NMe2, CF3,) complexes represent simple, general, and efficient catalysts for the Suzuki−Miyaura cross-coupling reactions of aryl halides including five-membered heteroaryl halides and heteroatom-substituted six-membered heteroaryl chlorides with a diverse range of arylboronic acids. High product yields (89−99% isolated yields) and turn-over-numbers (10 000 TON) are observed.

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History

  • Published In Issue April 27, 2006
  • Received January 31, 2006

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