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Letter

On-Water Chemistry: Copper-Catalyzed Straightforward Synthesis of Benzo[b]furan Derivatives in Neat Water^§

Supporting Info

Mónica Carril, Raul SanMartin,* Imanol Tellitu, and Esther Domínguez*

Kimika Organikoa II Saila, Zientzia eta Teknologia Fakultatea, Euskal Herriko Unibertsitatea, P.O. Box 644, 48080 Bilbao, Spain

Org. Lett., 2006, 8 (7), pp 1467–1470

DOI: 10.1021/ol060274c

Publication Date (Web): March 4, 2006

Dedicated to the memory of Prof. Marcial Moreno Mañas.

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, raul.sanmartin@ehu.es

Abstract

A more sustainable protocol leading to 2-alkyl- or 2-aryl-substituted benzo[b]furans is reported, involving a copper−TMEDA complex which catalyzes the transformation of readily available ketone derivatives into the corresponding benzofurans in good to excellent yields. The reaction is accomplished using water as the solvent without organic cosolvents, and one example of catalyst reutilization is also presented.

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Published In Issue March 30, 2006
Received February 1, 2006

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Letter

On-Water Chemistry: Copper-Catalyzed Straightforward Synthesis of Benzo[b]furan Derivatives in Neat Water^§