Letter
A Facile and Efficient Direct Aldol Addition of Simple Thioesters
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Abstract

Simple thioesters undergo direct aldol addition to aldehydes in the presence of MgBr2·OEt2 and i-Pr2NEt using untreated, reagent-grade CH2Cl2 under atmospheric conditions. The reactions proceed extremely rapidly and in excellent yield.
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History
- Published In Issue March 30, 2006
- Received February 16, 2006
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