A Facile and Efficient Direct Aldol Addition of Simple Thioesters

Julianne M. Yost, Guoqiang Zhou, and Don M. Coltart*
Department of Chemistry and the Center for Chemical Biology, Duke University, Durham, North Carolina 27708
Org. Lett., 2006, 8 (7), pp 1503–1506
DOI: 10.1021/ol060413q
Publication Date (Web): March 7, 2006
Copyright © 2006 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, don.coltart@duke.edu

Abstract

Abstract Image

Simple thioesters undergo direct aldol addition to aldehydes in the presence of MgBr2·OEt2 and i-Pr2NEt using untreated, reagent-grade CH2Cl2 under atmospheric conditions. The reactions proceed extremely rapidly and in excellent yield.

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History

  • Published In Issue March 30, 2006
  • Received February 16, 2006

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