Synthesis and Characterization of Glucosamine-Bound Near-Infrared Probes for Optical Imaging

Cong Li, Tiffany R. Greenwood, Zaver M. Bhujwalla, and Kristine Glunde*
JHU ICMIC Program, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
Org. Lett., 2006, 8 (17), pp 3623–3626
DOI: 10.1021/ol060783e
Publication Date (Web): July 26, 2006
Copyright © 2006 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, kglunde@mri.jhu.edu

Abstract

Abstract Image

Two novel near-infrared (NIR) fluorescent probes have been synthesized by linking a carbocyanine fluorophore and glucosamine through different linkers. These probes demonstrated a high quantum yield, low cytotoxicity, reversible pH-dependent fluorescence in the physiological pH range, and a decreased aggregation tendency in aqueous solutions. In vitro NIR optical imaging studies revealed cellular uptake and strong intracellular NIR fluorescence of these two probes in four breast epithelial cell lines.

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History

  • Published In Issue August 17, 2006
  • Received March 31, 2006

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