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Letter

Enantioselective One-Pot Three-Component Synthesis of Propargylamines

Supporting Info

Alakesh Bisai and Vinod K. Singh*

Department of Chemistry, Indian Institute of Technology, Kanpur, India 208 016

Org. Lett., 2006, 8 (11), pp 2405–2408

DOI: 10.1021/ol060793f

Publication Date (Web): May 6, 2006

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, vinodks@iitk.ac.in

Abstract

A copper(I) complex of i-Pr-pybox-diPh has been found to be an efficient catalyst for an enantioselective one-pot three-component synthesis of propargylamines from aldehydes, amines, and alkynes. The reaction has been applied to a wide variety of aromatic aldehydes with excellent yields (up to 99%) and enantiomeric excesses (up to 99% ee). A transition-state model has been proposed to explain the stereochemical outcome of the reaction.

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Published In Issue May 25, 2006
Received April 3, 2006

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Letter

Enantioselective One-Pot Three-Component Synthesis of Propargylamines

Abstract

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History

Recommend & Share

Related Content

Enantioselective Direct-Addition of Terminal Alkynes to Imines Catalyzed by Copper(I)pybox Complex in Water and in Toluene

The First Silver-Catalyzed Three-Component Coupling of Aldehyde, Alkyne, and Amine

Enantioselective Synthesis of Propargylamines through Zr-Catalyzed Addition of Mixed Alkynylzinc Reagents to Arylimines

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