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Letter

4,7-Dimethoxy-1,10-phenanthroline: An Excellent Ligand for the Cu-Catalyzed N-Arylation of Imidazoles

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Ryan A. Altman and Stephen L. Buchwald*

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Org. Lett., 2006, 8 (13), pp 2779–2782

DOI: 10.1021/ol0608505

Publication Date (Web): June 2, 2006

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, sbuchwal@mit.edu

Abstract

4,7-Dimethoxy-1,10-phenanthroline (L) was found to be an efficient ligand for the copper-catalyzed N-arylation of imidazole with aryl iodides and bromides under mild conditions. A variety of hindered and functionalized imidazoles and aryl halides were transformed in good to excellent yields.

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Published In Issue June 22, 2006
Received April 7, 2006

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Letter

4,7-Dimethoxy-1,10-phenanthroline: An Excellent Ligand for the Cu-Catalyzed N-Arylation of Imidazoles

Abstract

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SciFinder Links

History

Recommend & Share

Related Content

Highly Selective Room-Temperature Copper-Catalyzed C−N Coupling Reactions Highly Selective Room-Temperature Copper-Catalyzed C−N Coupling Reactions

The Copper-Catalyzed N-Arylation of Indoles

A General and Efficient Copper Catalyst for the Amidation of Aryl Halides

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