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Letter

Highly Enantioselective Synthesis of β-Amino Alcohols

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Thomas-Xavier Métro, Jérôme Appenzeller, Domingo Gomez Pardo,* and Janine Cossy*;

Laboratoire de Chimie Organique, associ au CNRS, Ecole Suprieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI), 10 rue Vauquelin, 75231 Paris Cedex 05, France

Org. Lett., 2006, 8 (16), pp 3509–3512

DOI: 10.1021/ol061133d

Publication Date (Web): July 7, 2006

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, domingo.gomez-pardo@espci.fr, ; , janine.cossy@espci.fr

Abstract

N,N-Dialkyl-β-amino alcohols derived from α-amino acids can be rearranged enantiospecifically by using TFAA/Et₃N/NaOH to give 1,2-amino alcohols with enantiomeric excess up to 99%.

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Published In Issue August 03, 2006
Received May 9, 2006

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Letter

Highly Enantioselective Synthesis of β-Amino Alcohols

Abstract

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History

Recommend & Share

Related Content

Highly Enantioselective Synthesis of β-Amino Alcohols: A Catalytic Version

Concise Synthesis of Chafurosides A and B

Organocatalytic Enantioselective Friedel−Crafts Alkylation of 4,7-Dihydroindoles with α,β-Unsaturated Aldehydes: An Easy Access to 2-Substituted Indoles

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