Pd/C-Catalyzed Chemoselective Hydrogenation in the Presence of Diphenylsulfide

Akinori Mori, Yumi Miyakawa, Eri Ohashi, Tomoko Haga, Tomohiro Maegawa, and Hironao Sajiki*
Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, Mitahora-higashi, Gifu 502-8585, Japan
Org. Lett., 2006, 8 (15), pp 3279–3281
DOI: 10.1021/ol061147j
Publication Date (Web): June 28, 2006
Copyright © 2006 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, sajiki@gifu-pu.ac.jp

Abstract

Abstract Image

A Pd/C-catalyzed chemoselective hydrogenation using diphenylsulfide as a catalyst poison has been developed. This methodology selectively hydrogenates olefin and acetylene functionalities without hydrogenolysis of aromatic carbonyls and halogens, benzyl esters, and N-Cbz protective groups.

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History

  • Published In Issue July 20, 2006
  • Received May 11, 2006

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