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Letter

Reaction of N-Monosubstituted Hydrazones with Nitroolefins: A Novel Regioselective Pyrazole Synthesis

Supporting Info

Xiaohu Deng* and Neelakandha S. Mani

Department of Drug Discovery, Johnson & Johnson Pharmaceutical R&D LLC, 3210 Merryfield Row, San Diego, California 92121

Org. Lett., 2006, 8 (16), pp 3505–3508

DOI: 10.1021/ol061226v

Publication Date (Web): July 7, 2006

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, xdeng@prdus.jnj.com

Abstract

A novel regioselective synthesis of substituted pyrazoles from N-monosubstituted hydrazones and nitroolefins is described. The reaction is performed in a one-pot manner and the yields range from moderate to excellent. A key nitropyrazolidine intermediate is characterized and a plausible mechanism is proposed.

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Published In Issue August 03, 2006
Received May 18, 2006

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Letter

Reaction of N-Monosubstituted Hydrazones with Nitroolefins: A Novel Regioselective Pyrazole Synthesis

Abstract

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SciFinder Links

History

Recommend & Share

Related Content

1,3-Diketones from Acid Chlorides and Ketones: A Rapid and General One-Pot Synthesis of Pyrazoles

Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation

Inhibition of human leukocyte elastase, porcine pancreatic elastase, and chymotrypsin by elasnin and other 4-hydroxy-2-pyrones

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