A Convenient Synthesis of 4-Alkyl-5-aminoisoxazoles

Matthew P. Bourbeau* and James T. Rider
Department of Medicinal Chemistry, Amgen Inc., 1 Amgen Center Drive, Thousand Oaks, California 91303
Org. Lett., 2006, 8 (17), pp 3679–3680
DOI: 10.1021/ol061260+
Publication Date (Web): July 20, 2006
Copyright © 2006 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, bourbeau@amgen.com

Abstract

Abstract Image

A series of 4-alkyl-5-aminoisoxazoles have been synthesized in high yield by nucleophilic addition of lithiated alkyl nitriles to (α)-chlorooximes. The scope and limitations of this reaction were examined by varying the nature of the nitrile and chloride oxime.

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History

  • Published In Issue August 17, 2006
  • Received May 23, 2006

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