Microwaves Make Hydroformylation a Rapid and Easy Process

Elena Petricci,† André Mann,‡ Angèle Schoenfelder,‡ Andrea Rota,§ and Maurizio Taddei*†
Dipartimento Farmaco Chimico Tecnologico, Universit degli Studi di Siena, Via A. Moro, 53100 Siena, Italy, CEM Italia srl, Via dell Artigianato, 6/8 24055 Cologno al Serio (BG), Italy, and Laboratoire de Pharmacochimie de la Communication Cellulaire, CNRS-UMR7175, 74, rue du Rhin, BP 60024, F-67401 Illkirch, France
Org. Lett., 2006, 8 (17), pp 3725–3727
DOI: 10.1021/ol061312v
Publication Date (Web): July 29, 2006
Copyright © 2006 American Chemical Society
†

 Università degli Studi di Siena.

,
‡

 CNRS-UMR7175.

,
§

 CEM Italia srl.

,
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, taddei.m@unisi.it

Abstract

Abstract Image

Hydroformylation of alkenes can be carried out in a few minutes under microwave activation at a relatively low pressure (40 psi) using commercially available catalysts and ligands. The 80 mL vial of a Discover microwave oven was connected to a cylinder of CO and H2, and after filling the reactor at 40 psi, a mixture of an alkene, the Wilkinson catalyst, and XANTPHOS was submitted to microwave irradiation giving, after 4 min, high conversion into the corresponding aldehyde without formation of the isomerized alkene.

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History

  • Published In Issue August 17, 2006
  • Received May 30, 2006

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