Palladium-Catalyzed Oxidation of Boc-Protected N-Methylamines with IOAc as the Oxidant:  A Boc-Directed sp3 C−H Bond Activation

Dong-Hui Wang, Xue-Shi Hao, Di-Fu Wu, and Jin-Quan Yu*
Department of Chemistry MS015, Brandeis University, Waltham, Massachusetts 02454-9110
Org. Lett., 2006, 8 (15), pp 3387–3390
DOI: 10.1021/ol061384m
Publication Date (Web): June 30, 2006
Copyright © 2006 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, yu200@brandeis.edu

Abstract

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Pd-catalyzed selective oxidation of Boc-protected N-methylamines with IOAc as the oxidant is described. Evidence for the involvement of a Boc-directed C−H activation process is provided.

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History

  • Published In Issue July 20, 2006
  • Received June 6, 2006

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