Gold(I)-Catalyzed Domino Ring-Opening Ring-Closing Hydroamination of Methylenecyclopropanes (MCPs) with Sulfonamides:  Facile Preparation of Pyrrolidine Derivatives

Min Shi,*† Le-Ping Liu,‡ and Jie Tang‡
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China, and Department of Chemistry, East China Normal University, 3663 Zhongshanbei Lu, Shanghai 200062, China
Org. Lett., 2006, 8 (18), pp 4043–4046
DOI: 10.1021/ol0614830
Publication Date (Web): August 12, 2006
Copyright © 2006 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

,
†

 Chinese Academy of Sciences.

,
‡

 East China Normal University.

, mshi@mail.sioc.ac.cn

Abstract

Abstract Image

Reaction of methylenecyclopropanes 1 with sulfonamides produces the corresponding pyrrolidine derivatives 3 in moderate to good yields under the catalysis of Au(I) via a domino ring-opening ring-closing hydroamination process.

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History

  • Published In Issue August 31, 2006
  • Received June 16, 2006

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