Novel and Efficient Synthesis of Iminocoumarins via Copper-Catalyzed Multicomponent Reaction

Sun-Liang Cui, Xu-Feng Lin, and Yan-Guang Wang*
Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China
Org. Lett., 2006, 8 (20), pp 4517–4520
DOI: 10.1021/ol061685w
Publication Date (Web): September 2, 2006
Copyright © 2006 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, orgwyg@zju.edu.cn

Abstract

Abstract Image

A variety of substituted iminocoumarins are prepared in good to excellent yields via a copper-catalyzed multicomponenet reaction of sulfonyl azides, terminal alkynes, and salicylaldehydes or o-hydroxylacetophenones. The method is general, mild, versatile, and efficient. A plausible mechanism for the domino process is proposed.

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History

  • Published In Issue September 28, 2006
  • Received July 9, 2006

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