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Letter

Gold-Catalyzed Tandem Cycloisomerization−Hydroalkoxylation of Homopropargylic Alcohols

Supporting Info

Volker Belting and Norbert Krause*

Organic Chemistry II, Dortmund University, D-44221 Dortmund, Germany

Org. Lett., 2006, 8 (20), pp 4489–4492

DOI: 10.1021/ol061751u

Publication Date (Web): September 9, 2006

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, norbert.krause@uni-dortmund.de

Abstract

The tandem cycloisomerization−hydroalkoxylation of various homopropargylic alcohols in the presence of an alcohol and a dual catalyst system, consisting of a gold precatalyst and a Brønsted acid, provides an efficient route to tetrahydrofuranyl ethers under mild reaction conditions. The reaction can be carried out in various solvents, including alcohol, with both terminal and internal alkynes as the substrate.

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Published In Issue September 28, 2006
Received July 17, 2006

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Letter

Gold-Catalyzed Tandem Cycloisomerization−Hydroalkoxylation of Homopropargylic Alcohols

Abstract

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SciFinder Links

History

Recommend & Share

Related Content

Ligand-Controlled Access to [4 + 2] and [4 + 3] Cycloadditions in Gold-Catalyzed Reactions of Allene-Dienes

Enantiospecific Total Syntheses of Kapakahines B and F

Phosphine-Promoted [3 + 3] Annulations of Aziridines With Allenoates: Facile Entry Into Highly Functionalized Tetrahydropyridines

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