Oxidative Mannich Reaction of N-Carbobenzyloxy Amines with 1,3-Dicarbonyl Compounds

Jun-ichi Matsuo,* Yumi Tanaki, and Hiroyuki Ishibashi*
Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
Org. Lett., 2006, 8 (19), pp 4371–4374
DOI: 10.1021/ol0618095
Publication Date (Web): August 16, 2006
Copyright © 2006 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, jimatsuo@p.kanazawa-u.ac.jp

Abstract

Abstract Image

Efficient carbon−carbon bond formation at the α-position of nitrogen was established by one-pot oxidative Mannich reaction of N-carbobenzyloxy (Cbz) amines with 1,3-dicarbonyl compounds using N-tert-butylbenzenesulfinimidoyl chloride as an oxidant.

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History

  • Published In Issue September 14, 2006
  • Received July 22, 2006

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