Direct and Efficient One-Pot Preparation of Ketones from Aldehydes Using N-tert-Butylphenylsulfinimidoyl Chloride

James J. Crawford, Kenneth W. Henderson, and William J. Kerr*
Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral Street, Glasgow, Scotland, U.K. G1 1XL, and Department of Chemistry and Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, Indiana 46556-5670
Org. Lett., 2006, 8 (22), pp 5073–5076
DOI: 10.1021/ol061903l
Publication Date (Web): October 5, 2006
Copyright © 2006 American Chemical Society

 Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde.

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 Department of Chemistry and Biochemistry, University of Notre Dame.

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*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, w.kerr@strath.ac.uk

Abstract

Abstract Image

A general, one-pot process has been established to prepare ketones from aldehydes using N-tert-butylphenylsulfinimidoyl chloride. By employing the developed protocol, a range of unsymmetrical ketones has been prepared in good yields from aldehydes in one simple synthetic operation.

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History

  • Published In Issue October 26, 2006
  • Received August 1, 2006

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